Wow, a brilliant article. Though I kept wondering that why sitting for long periods may cause inflammation of the muscle or around the spinal disc. Then I thought about this recent post I did on pain-sensing neurons being sufficient to induce inflammation. I checked and found some of the TRPV1+ nerve fibres that sense both pain and cause inflammation being involved in sciatic nerve injury. In fact, there are studies discussing blocking these ion channels as a potential analgesic for the treatment of pain relief in this condition. It makes me wonder that, if it is possible that chronically stressing these nerve fibres by your posture might lead to a slow accumulation of inflammation, which then ends up in a positive feedback loop of inflammation + pain -> activation of sensory fibres --> more inflammation and pain. I don't know if anyone has looked into this possibility. It would be interesting to see if type 17 immune response is what is keeping the cycle going.
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