RE: The quest for the elixir of life - Episode 4 - Tackling immunosenescence

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I am happy to have found this post tonight. I will probably have a look to the first three episodes during the next days. I unfortunately miss them…

I learned a few things around here, like those benefits about caloric restrictions. I know that having a proper diet contributes to a healthier life (when compared with calorimetric excesses), but I didn’t know it was affecting chronic diseases, and could affect how our immune system ages. I am looking forward to read the rest. I assume there is no unique combination of ways of living that stops ageing (otherwise we would know it, I guess), but I am wondering what else could impact it. I will probably have to wait a bit for an answer, won't I?



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I think CR is somewhat most consistent thing found to work in many animal models. Maybe in future, we will also figure out that more than calories it has been the synergistic effect of reducing certain molecules in the diet. It's interesting to use CR as a proxy, for now, to figure out the molecular pathways. If we know the pathways we can have some guess on what genes might be involved, what are the gene-environmental interactions apart from a diet that slows or accelerates ageing. If I compare the field of ageing with particle physics we have just shot electrons on a gold foil to guess the structure of atoms. It's a long way until we get to the standard model.

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