It's true that science challenges our perception of reality. However, in the world I more comfortably inhabit--literature--an insubstantial reality has been the subject of great writers for centuries.
Calderon de la Barca, E.T.A. Hoffmann, Miguel de Unamuno, Kafka, Borges... many, many writers have explored the nature of reality. How can we trust what we see, what we think we know?
I think there have always been people who wondered. Science gives us more tools, but no more security...or insecurity. Once we're not content to accept the orthodoxy of received truths, we're pretty much out on a limb, ontologically speaking.
Hope you don't mind my going off here.
I studied all these writers and your blog struck a chord. Great blog :)