RE: Can Nanoparticles take the place of synthetic fertilizers?

Once read that nanoparticles could cause cardiopulmonary problems and general inflammatory response. They are generally capable of crossing the cell membranes, now I wonder how about the blood-brain barrier? can they cross that too? if they can, what will be the effect if toxic amounts end up crossing the BBB, thinking also of cerebrovascular accidents in relation nanotoxicity.