RE: Normal Thyroid vs Papillary Thyroid Carcinoma

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We can see clearly the difference, do you think that this is one of the easiest ones to differentiate from a normal tissue behavior for a not trained eye?
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The differences here are on easy mode given that it's from tissue sections. When we get aspirate specimens, these can be difficult to appreciate especially for bloody smears. The classic features may not be readily distinguishable so further resampling may be recommended.

Tissue biopsy is recommended but the choice to operate isn't something to be taken lightly as one could require only one lobe to remove or two depending on the extent of tumor involvement on imaging.

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