The Complexity of Human Genetic Inheritance

in STEMGeeks2 months ago (edited)

Scenario 1

A newly married couple just moved into a serviced apartment with its own security guard. The husband was working in another state, although within the same country. Hence, he only comes home once a month, usually at the end of every month. The wife conceived and delivered a baby boy. But to the surprise of everyone, the baby looked so much like their security guard. The husband suspected foul play and decided to go for a paternity test. The result confirmed that he is actually the father of the baby. Still not contented, samples were sent to an international lab and the result came out the same. How come?

Scenario 2

A black Nigerian couple - Ben and Angela in the United Kingdom gave birth to a white baby. The first instinct of everyone back at home was that the wife must have cheated on the husband. Further inquiries actually showed that there was no case of infidelity on the part of the wife. Several hypotheses were formulated to support the possibility of such occurrence but none could be tested or confirmed.

Scenario 3

When my first son was given birth, she looked so much like his mum. A few months later, he looked like me in every way. He is two years now and one cannot really pick who exactly he looks like anymore. In fact, none of us the parent.

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....and the complexity goes on

The early days in my genetics class were very interesting and the only aspects that resonate quite well on my mind - and the minds of virtually everyone. Then, inheriting characters was as simple as just taking one allele from your mother and another from your father. When the two alleles come together, a genotype for a particular trait is formed. What would be expressed morphologically now depends on the dominance or recessiveness of each allele.

Taking human height as an example, if your father is short and your mother is tall with the tallness allele in your mother being dominant (meaning shortness is recessive), a combination of shortness allele and tallness allele from the respective parents will result in you being tall. In other words, the tallness of your mother will manifest in you.

If bother of your parents are homozygous for their respective traits, none of your siblings would be short as far as height is concerned. It all made sense to every one of us and we thought highly of ourselves as geneticists - not until we started treating topics relating to codominance, incomplete dominance, linkage, and gene interactions such as pleiotropy and epistasis.

From there, we also dabbled into sex-limited inheritance, cytoplasmic inheritance, Y-limited traits, and so on. Some aspects of the subject initially came as too complex to understand but with continuous practice and reading, many of us were able to grab it. Still some aspects of human inheritance exist that seem not to conform to any of the patterns that have been researched and established in Genetics.

It all started with the work of Gregor Mendel and everyone thought the codes of inheritance have been cracked. Then, a few exceptions to the laws of Mendel were first discovered. Later, scientists found out that the laws of Mendel were actually the exceptions to inheritance, and not the norm. Only a handful of traits in humans follow a simple dominance/recessive inheritance pattern and the interaction of multiple genes is often behind many of the traits we see expressed morphologically.

The truth is, even with the advancement in technology and the availability of sophisticated equipment to study chromosomes and inheritance, many things remain uncomprehended when it comes to humans. According to the Human Genome Project, an average human has between 20,000 and 25,000 genes. With the findings that genes on one the same or even separate chromosomes have the capacity to interact to produce a physical trait, one can only imagine the complexity of interactions that can happen with thousands of genes. Definitely not something that can be fully understood by scientists for a very long time - if ever.

Science has gone far in trying to understand nature. But in reality, the more we know as humans, the more the unknown increases.

If you have this far, I sincerely thank you for your time.

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wow, thanks for the simple explanations. My grandad was 6'2" tall and my grandma four feet tall. Some of us grandchildren took after grandpa and some after grandma and a few others like me are somewhere in the middle, lol. It sure is a complex world. Voted on behalf of the Neoxian city paper team.

Posted via neoxian.city | The City of Neoxian

Thanks for the support. It is indeed complex, but the little we understand so far has been helpful to answer some basic questions.

I am always being questioned why I have short hair since my mother and father have long hair, genetics are so complex, and sometimes there is so much we don't understand.

Found your post via @dreemport

Not sure humans can understand everything ever. The more we know, the more we do not know.

Exactly.

These things come true. My grandpa was a fair man, his complexion entered his eyes. Little wonder my uncle gave birth to an albino. That's the first of its kind in our fourth generation.
Thank you for this educative work. I found it via @dreemport.

Just imagine. The first albino in your family and I can only imagine what some people would be saying.

Science in general and genetics in particular has come so far but so much is still unclear which your post makes so evident

I found my way here via #dreemport

Thanks for the insight.

👍🙂👍

Your post makes me think of the saying that the more we learn about something, the more we realize how little we know about everything...

I got here via @dreemport

Yea. I actually left that quote somewhere in the post...lol. Thanks for the comment

I think I got so caught up in all the chromosomes and combinations of what is inherited and whatnot, that I didn't recognize the quote...lol!

Shame on me!

Anyway, it was still a great and very informative post! Keep up the good work!

The complexity of genes somehow confuses many. Heritable characters pass to the future generation but sometimes mutation can bring new diversity. The cases you have explained also point out the diversity.
Mandela the father of genetics simplified things in the form of dominance and recessive traits. But yes human genome project it's the evolution in the history of science.
Thanks to @dreemport for such a remarkable suggestion.

You're right, the nature is still beyond human despite all the science and progress is done in genetics. How would you describe when you see a human-like object born to an animal. I have read many such cases where this happened in cases of goats and cows. Now keep guessing what could have happened with those domestic animals! Reached via #dreemport

Guess we can only try as human, we can't really get to the bottom of these phenomena

It is so true that saying...that the more we know, the more we don't know. The realisation of the sheer complexity of genetics is just one area that humans are challenged with and by each and every day. I have heard a few of the things in your article before but nevertheless found it fascinating and informative. I have recently undergone genetic testing myself and found the clinical discussion afterwards extremely interesting. Thank you for sharing your knowledge with us. I came to your post via @dreemport.


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