Clear Cell Neoplasms from Different Organ of Origins

in STEMGeeks6 months ago

Showcasing how clear cell carcinomas look across different organs involved. Please note that this is a phenotypic expression where neoplastic cells have a characteristic hyperchromatic central to eccentric nuclei and abundant clear cytoplasm. These can have a different aberration at a genetic and molecular level but the end expression makes them look like clear cells. I only have three organs for this post from Ovaries, Kidney and Brain specimens.

I'm not going to go into details about how these came to be or prognosis. The post is simply sharing how the same characteristic of neoplastic cells are visibly the almost the same and yet found on different organ locations bearing different clinical implications.

Clear Cell Carcinoma of the Ovary

Taken at Low Power View (100x):

Clear Cell Carcinoma of the Ovary LPF.jpg

Taken at High Power View (400x)

Clear Cell Carcinoma of the Ovary HPF.jpg

I've never encountered this case before and the pictures came from a colleague's case which I borrowed for study.

Renal Clear Cell Carcinoma

Taken at Low Power Views (100x)

Renal Clear Cell Carcinoma LPF.jpg

Taken an High Power View (400x)

Renal Clear Cell Carcinoma HPF.jpg

I don't get to cut a lot of radical nephrectomy specimens so I've only seen two cases with renal clear cell carcinoma twice in my training.

A throwback on the Hemangioblastoma case with clear cells.

Taken at Low Power View (100x)

Taken at High Power View (400x)

I mentioned before that committing to Hemangioblastoma requires ruling out possible metastatic renal clear cell carcinoma metastasis because you can see the Renal Clear Cell Carcinoma above as an example of how morphology isn't enough sometimes.

Now imagine receiving a slide looking at these features and then no one tells you the origin of the specimen?

If you made it this far reading, thank you for your time.

Posted with STEMGeeks

 6 months ago 

Now imagine receiving a slide looking at these features and then no one tells you the origin of the specimen?

I know that all too well. I get specimens labeled "swabs" for sources here and there. The floor seems to have trouble understanding the source affects the diagnosis greatly when we recover organisms.

!discovery 37

Ikr? sometimes we receive pieces of flesh or aspirate smears where it takes hours to days worth of delay just to get in contact with the folks/institution that sent it. This tiny detail really grinds my gears as I have to go through different people just to search for the one that sent the specimen in the lab for reference.

 6 months ago 

Literally affects patient care.

Interesting how at 400x it becomes more clear what is happening!

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 6 months ago Reveal Comment