[文献阅读]20200604-癌细胞中发现了细菌并且在数量与偏好性上存在差异

重点:癌症细胞中存在细菌等微生物

2a247694223c498b6239ef75d9a89a0.jpg
(https://www.sciencemag.org/)

近年来,对微生物的研究十分火热。2010年的时候,我们才发现,原来人体的肠道存在着大量的微生物,他们的细胞数量甚至十倍于我们人体的细胞。

因为肠道是人体吸收消化的场所,所以自然而然,消化类疾病,代谢类的疾病首先开始与肠道微生物结合研究。肥胖,糖尿病,非酒精脂肪肝,癌症等等。。。都与肠道微生物有关。。。有的微生物是益生菌,有的是有害菌。。。

对了,研究这些微生物叫做宏基因组 (metagenomics),随着近年来研究的数量增加,大家逐渐往机制靠,希望做的透彻。于是,17年年底,上海瑞金Ningguang院士团队发现了与肥胖有关的细菌通过谷氨酰胺让人肥胖。上海交大的Zhao Liping院士发现某些益生菌能够让某些糖尿病药物的效果发挥的更好。

今日之前,我认为宏基因组的研究趋势,应该大抵如此了,应该往功能机制靠,做深,做透彻,但是今天的一篇文章让我深受启发。


文章是2020年5月29日发布在Science上的封面文章,题为 The human tumor microbiome is composed of tumor type–specific intracellular bacteria

文章指出人的许多肿瘤细胞中,也存在着一些细菌,不同肿瘤含有的量不同,并且细菌也有偏好性。

d21e0d82ea4ebd8a8d8d6a6f6631d86.jpg
(https://www.sciencemag.org/)

在查阅到癌症细胞中有细菌之外,Gut杂志2020年4月22日也报道了脂肪细胞中也含有细菌,题为 Adipose tissue-derived bacteria are associated with inflammation in obesity and type 2 diabetes

那么,他们究竟有什么用呢?有益还是有害?又是怎么进入的?别的细胞是否也存在细菌?新生宝宝的细胞中是否也存在呢?

一条与以往大相径庭的研究道路,突然就出现在了眼前,新的发现,带来了新的挑战,令人兴奋鼓舞。

负重前行,任重道远,千里之行,始于足下,加油!JY

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Sorry, I am a newcomer, I don't know how to operate.

I hope to add the tag of hive-105017 to this post, so I reposted it. But the previous post seems to be unable to delete (I tried many times).

Thank you for your reminder, I will pay attention later.

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