FROM ARTIFICIAL OVARIES, CLONING- THE ENGINEERED OVARIAN SCAFFOLD SOLVING CANCER COMPLICATIONS IN FEMALE REPRODUCTIVE SYSTEM(Revised)

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UFOs were tagged myths and people who claimed to have seen one were called nuts or brandish Conspiracy theorists. Not until recently CNN admits UFOs where real, and the presence of another higher lifeform is not a hoax. Human cloning will get to that stage too.

For years it is being arugued to be a real thing. Although mainstream media will not admit that yet, it will take a strong push for that to happen. Be thou as it may, there's "beauty in the ashes" if human cloning is actually existing already.

To some, this is good news and to others; it is a more sinister plan of the New World Order. Either way, there is a research nearing completion on an engineered ovarian scaffold that might help young female cancer survivors or cancer patients to preserve their fertility and their chances of conceiving after a cancer treatment.

If you recall from basic Biology, and if you don’t which is not a crime; the ovary is the female reproductive/sex organ that produces eggs to produce offspring.

An on-going research that had eyebrows raised; does this mean artificial humans will exist soonest? A question that sounds clueless, is there anyone who still doesn’t know about human cloning? There has been dozens of documented researches and sucessful cloning of A Sheep ( Dolly), and there several other findings backing up these claims.

However, it is a question of if science will ever justify morality of human cloning which has been a subject of fierce debate among scientist and scholars, some in full support and others against it. Either ways, it is one of the revolutionary breakthroughs in the present day science and technology!

A clone could be classified as artificial, just to be clear; one of the reasons why the engineered artificial ovary is been frowned upon by the public irrespective of the problems of conception it is acclaimed to solve in cancer patients. Social media ran amok over the news on CNN, considering the overpopulated status of the world without sufficient resources for everyone alive, and the yet unborn.

“Artificial human ovaries have been made for the primary time in a breakthrough that guarantees trust for barren women. Scientists effectively united follicles, the antecedents to eggs, onto an organic “scaffold” which at that point developed regularly.”- The Telegraph

Nevertheless, the artificial ovary is a fantastic futuristic idea that might be achievable for commercial purposes in a matter of years for sterile females and for those who had to undergo cancer treatments, solving a couple of related ovarian complications like the cyst, ovarian cancers, ruptured ovaries etc.

It has been clinically proven that both radiotherapy and chemotherapy usually damage and destroy the natural functions of the ovary among other things like accidents and multiple abortions, this latest research could lead to a new option for cancer patients with the hope of having fertility after chemo treatment or its alternative which is discussed below.

Females with cancer, they have two options of treatment, unfortunately, this two forms of treatment often affect the reproduction of ladies, eliminating chances of the ovary to produce eggs necessary for conception.

Around 2% of ladies of conceptive age (that could get pregnant) who have growth and experience cancer treatment are in danger of losing their ovarian capacity - and therefore their richness. They are pushed into untimely menopause, and despite the fact that the utilization of hormone substitution treatment and their own cryopreserved eggs enables a portion of these ladies to wind up pregnant, their regular hormones and characteristic richness won't be restored.

Scaling these hurdles, there were two methods to preserve the chances of fertility; with one of the options not used often more than the other because of the adverse relapse cases e.g high risk of cancer regrowth. These methods are;

  • Removal and freezing of some of the cancer patients eggs before treatment and after treatment when she is ready to have a child, then in-vitro fertilization is introduced to the particular subject.

  • The second option poses a great risk of reintroduction of cancer into the system, it involves ovarian tissue being removed before the treatment, which might contain malignant cells and, on implantation, the reintroduction of cancer is imminent in the subject's body.

”The artificial ovary will consist of a scaffold (originating from the woman’s own tissue or from a donated tissue) combined with her own follicles. It is newly constructed but biological”-Source

”We theorized that, if we could bioengineer an ovarian tissue scaffold that is free of cancer, we could seed it with previously frozen early-stage follicles, which then might develop and mature naturally. Ultimately, this could restore a woman's fertility.”- Dr. Susanne Pors, co-author of the study and postdoctoral fellow in the Laboratory of Reproductive Biology at the University Hospital of Copenhagen Rigs Hospitalet-Source

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To begin with, they tested on human tissue donated by patients who wish to conserve their being fertile. Employing a three-day chemical preparation and processes, the analysts killed all cells that may contain cancer from the tissue. The small secretory gland, in particular, is not at all like ovarian tissue cells, it doesn’t contain cancer, the follicle is shaped amid formation [when no cancer is imminent] and is encompassed by a basal layer that does not permit cancer cells to enter.

The chemical procedure cleared out a "decellularized platform" made up of proteins and collagens; the ordinary fabric that interfaces cells. The analysts/scientist seeded this auxiliary lattice with early-stage follicles. As trusted, the fabric allowed communication between the cells and permitted them to pro-create this improvement happened in vitro, or external part of the body.

Secondly, the analysts tested with mice and transplanted a decellularized and seeded network into the creatures. This upheld survival and development of the early-stage follicles. It is the very first time that disconnected human follicles have survived in a decellularized human framework. This may offer a modern methodology in reproduction/fertility conservation without chance of cancer reoccurrence.

With more research still underway, the development is liable to work other renowned scientist applauded the research work but with still a bit of doubt;

”a very interesting and novel approach to fertility preservation. It is not possible to tell until the data from this research group have been peer-reviewed by the scientific community and published in a scientific journal.”

"At this stage, many questions remain, this could give rise to a problem in itself, however, as the surrounding ovarian cells left behind might be required for the ovary to function fully”- Dr. Richard Anderson, a professor and head of obstetrics and gynecology at the University of Edinburgh.-Source

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[Image Credit; Pixabay Commons]

One of the positive lookouts is the report, which states that approximately a sum of 318 ladies worldwide had experienced ovarian tissue exchanges, with nine getting an analysis of tumor thereafter (in all cases not straightforwardly caused by the methodology). Restored hormonal capacity happened in 95% of these ladies, and in excess of 100 kids have been created/formed after the tissue exchanges.

This is a huge advantage, If this is the best option for fertility for sterile and cancer patients, it is not certain yet but this approach speaks tones in encouraging more advancement in protecting and preserving a woman's ability to conceive from the effect of cancer medicines, specialists confirmed.

References;
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